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Article

Compromised adenosine-A2AR axis contributes to recurrent spontaneous abortion by promoting proinflammatory macrophage polarization

14 May 2025

Abstract excerpt

This study investigates the association between recurrent spontaneous abortion (RSA) and macrophage polarization, exploring adenosine (Ado) as a potential biomarker and therapeutic target. By analyzing decidual tissues from RSA patients and normal pregnancies, we found reduced CD39 expression and lower adenosine levels in RSA, accompanied by increased M1 macrophage polarization and decreased M2 macrophage...

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PMID: 40373597
DOI: 10.1016/j.intimp.2025.114838

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