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Article

Thermal Stabilization of a Bacterial Zn(II)-Dependent Phospholipase C through Consensus Sequence Design.

Biochemistry - 6 Feb 2024

Val Diego S, Di Nardo Luisina, Marchisio Fiorela, Peiru Salvador, Castelli María Eugenia, Abriata Luciano Andrés, Menzella Hugo G, Rasia Rodolfo M

Abstract excerpt

Proteins' extraordinary performance in recognition and catalysis has led to their use in a range of applications. However, proteins obtained from natural sources are oftentimes not suitable for direct use in industrial or diagnostic setups. Natural proteins, evolved to optimally perform a task in physiological conditions, usually lack the stability required to be used in harsher conditions. Therefore, the...

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PMID: 38206322
DOI: 10.1021/acs.biochem.3c00509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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