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Article

The consensus concept for thermostability engineering of proteins.

Biochimica et biophysica acta - 29 Dec 2000

Lehmann M, Pasamontes L, Lassen S F, Wyss M

Abstract excerpt

Previously, sequence comparisons between a mesophilic enzyme and a more thermostable homologue were shown to be a feasible approach to successfully predict thermostabilizing amino acid substitutions. The 'consensus approach' described in the present paper shows that even a set of amino acid sequences of homologous, mesophilic enzymes contains sufficient information to allow rapid design of a thermostabilized,...

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PMID: 11150616
DOI: 10.1016/s0167-4838(00)00238-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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