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Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality

3 Jan 2024

Abstract excerpt

Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a...

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PMID: 38199039
DOI: 10.1016/j.redox.2023.103018

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