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Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age

9 Jan 2024

Abstract excerpt

In the early 1990's a group of unrelated genes were identified from the sites of recurring translocations in B-cell lymphomas. Despite sharing the nomenclature 'Bcl', and an association with blood-borne cancer, these genes have unrelated functions. Of these genes, BCL2 is best known as a key cancer target involved in the regulation of caspases and other cell viability mechanisms. BCL3 on the other hand was...

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PMID: 38195591
DOI: 10.1186/s12943-023-01922-8

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