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Article

Unraveling the function and structure impact of deleterious missense SNPs in the human OX1R receptor by computational analysis.

Scientific reports - 8 Jan 2024

Farajzadeh-Dehkordi Mahvash, Mafakher Ladan, Harifi Abbas, Haghdoost-Yazdi Hashem, Piri Hossein, Rahmani Babak

Abstract excerpt

The orexin/hypocretin receptor type 1 (OX1R) plays a crucial role in regulating various physiological functions, especially feeding behavior, addiction, and reward. Genetic variations in the OX1R have been associated with several neurological disorders. In this study, we utilized a combination of sequence and structure-based computational tools to identify the most deleterious missense single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38191899
DOI: 10.1038/s41598-023-49809-4
PMCID: PMC10774445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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