Article
Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations.
Molecules (Basel, Switzerland) - 23 Jun 2022
Fatima Munazza Tamkeen, Islam Zeyaul, Kolatkar Prasanna R, Al-Shabeeb Akil Ammira Sarah
Abstract excerpt
Obesity is a chronic disease with increasing cases among children and adolescents. Melanocortin 4 receptor (MC4R) is a G protein-coupled transporter involved in solute transport, enabling it to maintain cellular homeostasis. MC4R mutations are associated with early-onset severe obesity, and the identification of potential pathological variants is crucial for the clinical management of patients with obesity. A...
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