Article
Genetic analyses identify brain imaging-derived phenotypes associated with the risk of intracerebral hemorrhage.
Cerebral cortex (New York, N.Y. : 1991) - 31 Jan 2024
Liu Yi, Jia Yiming, Sun Hongyan, Sun Lulu, Wang Yinan, Xu Qingyun, He Yu, Chang Xinyue, Guo Daoxia, Shi Mengyao, Chen Guo-Chong, Zheng Jin, Zhu Zhengbao
Abstract excerpt
Previous observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and intracerebral hemorrhage (ICH), but the causality between them remains uncertain. We aimed to investigate the potential causal relationship between IDPs and ICH by a two-sample Mendelian randomization (MR) study. We selected genetic instruments for 363 IDPs from a genome-wide association study (GWASs)...
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