Article
Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage.
Stroke - 1 Jun 2013
Devan William J, Falcone Guido J, Anderson Christopher D, Jagiella Jeremiasz M, Schmidt Helena, Hansen Björn M, Jimenez-Conde Jordi, Giralt-Steinhauer Eva, Cuadrado-Godia Elisa, Soriano Carolina, Ayres Alison M, Schwab Kristin, Kassis Sylvia Baedorf, Valant Valerie, Pera Joanna, Urbanik Andrzej, Viswanathan Anand, Rost Natalia S, Goldstein Joshua N, Freudenberger Paul, Stögerer Eva-Maria, Norrving Bo, Tirschwell David L, Selim Magdy, Brown Devin L, Silliman Scott L, Worrall Bradford B, Meschia James F, Kidwell Chelsea S, Montaner Joan, Fernandez-Cadenas Israel, Delgado Pilar, Greenberg Steven M, Roquer Jaume, Lindgren Arne, Slowik Agnieszka, Schmidt Reinhold, Woo Daniel, Rosand Jonathan, Biffi Alessandro
Abstract excerpt
BACKGROUND AND PURPOSE: Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genome-wide data...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.