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Article

Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach.

Neurology - 22 Oct 2024

Muiño Elena, Carcel-Marquez Jara, Llucià-Carol Laia, Gallego-Fabrega Cristina, Cullell Natalia, Lledós Miquel, Martín-Campos Jesús M, Villatoro-González Paula, Sierra-Marcos Alba, Ros-Castelló Victoria, Aguilera-Simón Ana, Marti-Fabregas Joan, Fernandez-Cadenas Israel

Abstract excerpt

BACKGROUND AND OBJECTIVES: Genome-wide association studies (GWASs) have only 2 loci associated with spontaneous intracerebral hemorrhage (ICH): APOE for lobar and 1q22 for nonlobar ICH. We aimed to discover new loci through an analysis that combines correlated traits (multi-trait analysis of GWAS [MTAG]) and explore a gene-based analysis, transcriptome-wide association study (TWAS), and proteome-wide association...

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Identifiers

PMID: 39298701
DOI: 10.1212/WNL.0000000000209666
PMCID: PMC11446162

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