Article
Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2024
Anbinselvam Arularasan, Akinshipo Abdul-Warith O, Adisa Akinyele O, Effiom Olajumoke A, Zhu Xinhe, Adebiyi Kehinde E, Arotiba Godwin T, Akintoye Sunday O
Abstract excerpt
BACKGROUND: Ameloblastoma is an aggressively growing, highly recurrent odontogenic jaw tumor. Its association with BRAFV600E mutation is an indication for BRAFV00E-inhibitor therapy The study objective was to identify a sensitive low-cost test for BRAFV600E-positive ameloblastoma. We hypothesized that immunohistochemical staining of formalin-fixed paraffin-embedded tissues for BRAFV600E mutation is a low-cost...
Topics
- Humans
- Ameloblastoma
- Proto-Oncogene Proteins B-raf
- Mutation
- Odontogenic Tumors
- Formaldehyde