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Article

Precision therapy for BRAF V600E-mutated ameloblastoma: Systematic review insights.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery - 1 Jul 2026

Zhou Yuqing, Yi Jingrui, Momen-Heravi Fatemeh, Che Yinfu, Li Ruifang, Man Qiwen

Abstract excerpt

Although rare, ameloblastoma is a locally aggressive odontogenic tumor, with recent studies identifying the BRAF V600E mutation as its most common molecular alteration driving MAPK pathway activation. To elucidate its clinicopathological and therapeutic significance, we conducted a systematic review and meta-analysis of studies reporting both the prevalence of BRAF V600E and treatment outcomes in mutated cases. A...

Topics

Ameloblastoma
Humans
Proto-Oncogene Proteins B-raf
Mutation
Precision Medicine
Jaw Neoplasms
Molecular Targeted Therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41980527
DOI: 10.1016/j.jcms.2026.104566

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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