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Article

Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma.

Communications biology - 5 Jan 2024

Ren Qian-Nan, Huang Dan-Hui, Zhang Xiao-Nan, Wang Yue-Ning, Zhou Yu-Feng, Zhang Mei-Yin, Wang Shuo-Cheng, Mai Shi-Juan, Wu De-Hua, Wang Hui-Yun

Abstract excerpt

The androgen receptor (AR) plays an important role in male-dominant hepatocellular carcinoma, and specific acquired somatic mutations of AR have been observed in HCC patients. Our previous research have established the role of AR wild type as one of the key oncogenes in hepatocarcinogenesis. However, the role of hepatic acquired somatic mutations of AR remains unknown. In this study, we identify two crucial...

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Identifiers

PMID: 38182647
DOI: 10.1038/s42003-023-05704-2
PMCID: PMC10770045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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