Article
Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma.
International journal of cancer - 15 Apr 2007
Yeh Shiou-Hwei, Chiu Chi-Ming, Chen Chi-Ling, Lu Shu-Fen, Hsu Hey-Chi, Chen Ding-Shinn, Chen Pei-Jer
Abstract excerpt
Androgen and androgen receptor (AR) have long been implicated in liver carcinogenesis, especially for the male dominance feature. However, whether AR gene could occur in somatic mutations that might contribute to this process has not yet been studied. DNA sequencing and genotyping were conducted for detecting the genetic aberrations of AR gene in 257 primary hepatocellular carcinomas (HCCs) and also the...
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