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Liver-specific androgen receptor knockout attenuates early liver tumor development in zebrafish

23 Jul 2019

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most severe cancer types and many genetic and environmental factors contribute to the development of HCC. Androgen receptor (AR) signaling is increasingly recognized as one of the important factors associated with HCC. Previously, we have developed an inducible HCC model in kras transgenic zebrafish. In the present study, to investigate the role of AR in liver tumor...

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PMID: 31337771
DOI: 10.1038/s41598-019-46378-3

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