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Article

AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.

Cell death & disease - 18 May 2022

Kim Hyunjoo, Jeong Muhah, Na Do-Hyeong, Ryu Shin-Hyeon, Jeong Eun Il, Jung Kwangmin, Kang Jaemin, Lee Ho-June, Sim Taebo, Yu Dae-Yeul, Yu Hee Chul, Cho Baik-Hwan, Jung Yong-Keun

Abstract excerpt

The RAS-BRAF signaling is a major pathway of cell proliferation and their mutations are frequently found in human cancers. Adenylate kinase 2 (AK2), which modulates balance of adenine nucleotide pool, has been implicated in cell death and cell proliferation independently of its enzyme activity. Recently, the role of AK2 in tumorigenesis was in part elucidated in some cancer types including lung adenocarcinoma and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35585049
DOI: 10.1038/s41419-022-04921-7
PMCID: PMC9117275

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