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Article

A Novel Role for Coilin in Vertebrate Innate Immunity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Apr 2025

McLaurin Douglas M, Tucker Sara K, Siddique Shanzida J, Challagundla Lavanya, Gibert Yann, Hebert Michael D

Abstract excerpt

Coilin is a protein localized in the nucleus, where it plays a role in the assembly of the Cajal Body and is involved in ribonucleoprotein biogenesis. Our recent research has uncovered new roles for coilin, including its involvement in producing microRNAs and in modifying other proteins through phosphorylation and SUMOylation. We also proposed that coilin could respond to stress signals. In plants, coilin has...

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Identifiers

PMID: 40277349
DOI: 10.1096/fj.202403276R
PMCID: PMC12023821

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