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Estimation of age of onset and progression of breast cancer by absolute risk dependent on polygenic risk score and other risk factors.

Cancer - 1 May 2024

Bhatt Rikesh, van den Hout Ardo, Antoniou Antonis C, Shah Mitul, Ficorella Lorenzo, Steggall Emily, Easton Douglas F, Pharoah Paul D P, Pashayan Nora

Abstract excerpt

BACKGROUND: Genetic, lifestyle, reproductive, and anthropometric factors are associated with the risk of developing breast cancer. However, it is not yet known whether polygenic risk score (PRS) and absolute risk based on a combination of risk factors are associated with the risk of progression of breast cancer. This study aims to estimate the distribution of sojourn time (pre-clinical screen-detectable period)...

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Identifiers

PMID: 38174903
DOI: 10.1002/cncr.35183
PMCID: PMC7615824

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