Article
Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women.
Breast cancer research : BCR - 2 Jan 2024
Zirpoli Gary R, Pfeiffer Ruth M, Bertrand Kimberly A, Huo Dezheng, Lunetta Kathryn L, Palmer Julie R
Abstract excerpt
BACKGROUND: Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory performance as measured by the AUC (area under the curve). Following publication of the first PRS to perform well in women of African ancestry (AA-PRS), we conducted an external validation of the AA-PRS...
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