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Article

Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.

JAMA network open - 1 Jun 2026

Sun Yijia, Simmons Timothy, Li James L, Jamal Armaan, Manirakiza Achille V C, Pruss Dmitry, Ratzel Sarah, Olopade Olufunmilayo I, Gutin Alexander, Hughes Elisha, Huo Dezheng

Abstract excerpt

Importance: Validating polygenic risk scores (PRSs) as a breast cancer (BC) risk stratification tool in high-risk clinical settings is essential for potential clinical implementation. Objective: To evaluate the performance of African-ancestry PRSs for overall BC and triple-negative BC (TNBC) in an independent African American cohort at elevated familial risk. Design, Setting, and Participants: This case-control...

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Identifiers

PMID: 42307944
DOI: 10.1001/jamanetworkopen.2026.19285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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