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Article

STAT3 is over-activated within CD163pos bone marrow macrophages in both Multiple Myeloma and the benign pre-condition MGUS.

Cancer immunology, immunotherapy : CII - 1 Jan 2022

Andersen Morten N, Andersen Niels F, Lauridsen Kristina L, Etzerodt Anders, Sorensen Boe S, Abildgaard Niels, Plesner Trine, Hokland Marianne, Møller Holger J

Abstract excerpt

Tumour-associated macrophages (TAMs) support cancer cell survival and suppress anti-tumour immunity. Tumour infiltration by CD163pos TAMs is associated with poor outcome in several human malignancies, including multiple myeloma (MM). Signal transducer and activator of transcription 3 (STAT3) is over-activated in human cancers, and specifically within TAMs activation of STAT3 may induce an immunosuppressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34061243
DOI: 10.1007/s00262-021-02952-1
PMCID: PMC10992042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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