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FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery.

SLAS discovery : advancing life sciences R & D - 1 Apr 2024

Wang Yao, Cortes Enrico, Huang Ricky, Wan Jeremy, Zhao Junyi, Hinz Boris, Damoiseaux Robert, Pushkarsky Ivan

Abstract excerpt

The pivotal role of myofibroblast contractility in the pathophysiology of fibrosis is widely recognized, yet HTS approaches are not available to quantify this critically important function in drug discovery. We developed, validated, and scaled-up a HTS platform that quantifies contractile function of primary human lung myofibroblasts upon treatment with pro-fibrotic TGF-β1. With the fully automated assay we...

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Identifiers

PMID: 38158044
DOI: 10.1016/j.slasd.2023.12.010

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