Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging‐Associated ALKBH5‐m 6 A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2

29 Dec 2023

Abstract excerpt

Background Chemotherapy‐induced cardiovascular disease is a growing concern in the elderly population who have survived cancer, yet the underlying mechanism remains poorly understood. We investigated the role of ALKBH5 (AlkB homolog 5), a primary N 6 ‐methyladenosine (m 6 A) demethylase, and its involvement in m 6 A methylation‐mediated regulation of targets in aging‐associated doxorubicin‐induced cardiotoxicity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Peptidase Inhibition and Analysis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38156523
DOI: 10.1161/jaha.123.031353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging‐Associated ALKBH5‐m 6 A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2PMID 38156523Read ↗

m6A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3Semantic proximity Read ↗

The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart FailureSemantic proximity Read ↗

m <sup>6</sup> A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancerSemantic proximity Read ↗

m⁶A Demethylase ALKBH5 Promotes Tumor Cell Proliferation by Destabilizing IGF2BPs Target Genes and Worsens the Prognosis of Patients with Non-Small Cell Lung CancerSemantic proximity Read ↗

The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytesSemantic proximity Read ↗

N6-methyladenine demethylase ALKBH5 alleviates cardiomyocytes apoptosis via modulating m6A/SIRT1 mannerSemantic proximity Read ↗

ALKBH5 mediated RNA N6-methyladenosine demethylation protects against myocardial I/R induced injury via FSP1 dependent inhibition of ferroptosisSemantic proximity Read ↗

Identification of Genes and Pathways Regulated by Lamin A in Heart.Semantic proximity Read ↗

Molecular Mechanisms of Cardiomyocyte AgingSemantic proximity Read ↗

Conserved RNA–protein modules link early anthracycline responses to atrial fibrillation riskSemantic proximity Read ↗

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytesSemantic proximity Read ↗

Cardiomyocyte-derived Wnt5a drives doxorubicin-induced cardiomyopathy by amplifying cellular senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.