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STELLATE GANGLION BLOCK REVERSES PHSML-INDUCED VASCULAR HYPOREACTIVITY THROUGH INHIBITING AUTOPHAGY-MEDIATED PHENOTYPIC TRANSFORMATION OF VSMCs.

Shock (Augusta, Ga.) - 1 Mar 2024

Li Cai-Juan, Du Hui-Bo, Zhao Zhen-Ao, Sun Qi, Li Yi-Ming, Chen Si-Jie, Zhang Hong, Zhang Nan, Niu Chun-Yu, Zhao Zi-Gang

Abstract excerpt

ABSTRACT: Posthemorrhagic shock mesenteric lymph (PHSML) return-contributed excessive autophagy of vascular smooth muscle cells (VSMCs) is involved in vascular hyporeactivity, which is inhibited by stellate ganglion block (SGB) treatment. The contractile phenotype of VSMCs transforms into a synthetic phenotype after stimulation with excessive autophagy. Therefore, we hypothesized that SGB ameliorates...

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PMID: 38150357
DOI: 10.1097/SHK.0000000000002289

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