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Induction of Translational Readthrough on Protein Tyrosine Phosphatases Targeted by Premature Termination Codon Mutations in Human Disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Torices Leire, Nunes-Xavier Caroline E, Mingo Janire, Luna Sandra, Erramuzpe Asier, Cortés Jesús M, Pulido Rafael

Abstract excerpt

Nonsense mutations generating premature termination codons (PTCs) in various genes are frequently associated with somatic cancer and hereditary human diseases since PTCs commonly generate truncated proteins with defective or altered function. Induced translational readthrough during protein biosynthesis facilitates the incorporation of an amino acid at the position of a PTC, allowing the synthesis of a complete...

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Identifiers

PMID: 38147205
DOI: 10.1007/978-1-0716-3569-8_1

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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