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Article

Effect of Readthrough Treatment in Fibroblasts of Patients Affected by Lysosomal Diseases Caused by Premature Termination Codons.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2015

Matalonga Leslie, Arias Ángela, Tort Frederic, Ferrer-Cortés Xènia, Garcia-Villoria Judit, Coll Maria Josep, Gort Laura, Ribes Antonia

Abstract excerpt

Aminoglycoside antibiotics, such as gentamicin, may induce premature termination codon (PTC) readthrough and elude the nonsense-mediated mRNA decay mechanism. Because PTCs are frequently involved in lysosomal diseases, readthrough compounds may be useful as potential therapeutic agents. The aim of our study was to identify patients responsive to gentamicin treatment in order to be used as positive controls to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26169295
DOI: 10.1007/s13311-015-0368-4
PMCID: PMC4604176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of Readthrough Treatment in Fibroblasts of Patients Affected by Lysosomal Diseases Caused by Premature Termination Codons.PMID 26169295Read ↗

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