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Article

Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia.

Journal of biochemistry - 1 Aug 2020

Yesmin Farhana, Bhuiyan Robiul H, Ohmi Yuhsuke, Ohkawa Yuki, Tajima Orie, Okajima Tetsuya, Furukawa Keiko, Furukawa Koichi

Abstract excerpt

The readthrough of premature termination codon (PTC) by ribosome sometimes produces full-length proteins. We previously reported a readthrough of PTC of glycosyltransferase gene B4GALNT1 with hereditary spastic paraplegia (HSP). Here we featured the readthrough of B4GALNT1 of two mutants, M4 and M2 with PTC by immunoblotting and flow cytometry after transfection of B4GALNT1 cDNAs into cells. Immunoblotting showed...

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PMID: 32282910
DOI: 10.1093/jb/mvaa041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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