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Article

Probing the Dissociation Pathway of a Kinetically Labile Transthyretin Mutant.

Journal of the American Chemical Society - 10 Jan 2024

Sun Xun, Ferguson James A, Leach Benjamin I, Stanfield Robyn L, Dyson H Jane, Wright Peter E

Abstract excerpt

Aggregation of transthyretin (TTR) is associated with devastating amyloid diseases. Amyloidosis begins with the dissociation of the native homotetramer (a dimer of dimers) to form a monomeric intermediate that assembles into pathogenic aggregates. This process is accelerated in vitro at low pH, but the process by which TTR dissociates and reassembles at neutral pH remains poorly characterized due to the low...

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Identifiers

PMID: 38134439
DOI: 10.1021/jacs.3c10083
PMCID: PMC10926950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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