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Article

Water Plays Key Roles in Stabilities of Wild Type and Mutant Transthyretin Complexes.

Journal of the American Society for Mass Spectrometry - 7 Aug 2024

Lantz Carter, Rider Robert L, Yun Sangho D, Laganowsky Arthur, Russell David H

Abstract excerpt

Transthyretin (TTR), a 56 kDa homotetramer that is involved in the transport of thyroxine and retinol, has been linked to amyloidosis through disassembly of tetramers to form monomers, dimers, and trimers that then reassemble into higher order oligomers and/or fibrils. Hybrid TTR (hTTR) tetramers are found in heterozygous individuals that express both wild type TTR (wt-TTR) and mutant TTR (mTTR) forms of the...

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PMID: 39057193
DOI: 10.1021/jasms.4c00170
PMCID: PMC11311534

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