Article

Probing the dissociation pathway of a kinetically labile transthyretin mutant

2023-06-22

Abstract excerpt

Aggregation of transthyretin (TTR) is associated with devastating TTR amyloid disease. Amyloidosis begins with dissociation of the native tetramer to form a monomeric intermediate that assembles into pathogenic aggregates. This process is accelerated in vitro at low pH, but the dissociation and reassembly of TTR at neutral pH remains poorly understood, due to the low population of intermediates. We use NMR studies...

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Literature Corpus work: 8607059a-42da-5ba3-850f-fb4fcad5adce
DOI: 10.1101/2023.06.21.545798

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