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Article

Different disease-causing mutations in transthyretin trigger the same conformational conversion.

Protein engineering, design & selection : PEDS - 1 Mar 2008

Steward Robert E, Armen Roger S, Daggett Valerie

Abstract excerpt

Transthyretin (TTR)-containing amyloid fibrils are deposited in cardiac tissue as a natural consequence of aging. A large number of inherited mutations lead to amyloid diseases by accelerating TTR deposition in other organs. Amyloid formation is preceded by a disruption of the quaternary structure of TTR and conformational changes in the monomer. To study conformational changes preceding the formation of amyloid,...

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Source

Identifiers

PMID: 18276611
DOI: 10.1093/protein/gzm086

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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