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Article

Mutation and low pH effect on the stability as well as unfolding kinetics of transthyretin dimer.

Biophysical chemistry - 1 May 2014

Xue Qiao, Zheng Qing-Chuan, Zhang Ji-Long, Cui Ying-Lu, Chu Wen-Ting, Zhang Hong-Xing

Abstract excerpt

Transthyretin (TTR) dissociation and aggregation appear to cause several amyloid diseases. TTR dimer is an important intermediate that is hard to be observed from the biological experiments. To date, the molecular origin and the structural motifs for TTR dimer dissociation, as well as the unfolding process have not been rationalized at atomic resolution. To this end, we have investigated the effect of low pH and...

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Source

Identifiers

PMID: 24632442
DOI: 10.1016/j.bpc.2014.02.002

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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