Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.

doi:10.1006/jmbi.1998.1937

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Article

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.

Journal of molecular biology - 21 Aug 1998

Nettleton E J, Sunde M, Lai Z, Kelly J W, Dobson C M, Robinson C V

Abstract excerpt

Wild-type and variant transthyretins form amyloid fibrils in two different diseases. The biologically active form of transthyretin is a tetramer but there is evidence that a monomeric species is the amyloidogenic intermediate. Using mass spectrometry we have developed an approach to monitor the p...

Topics

Amyloid
Hydrogen
Hydrogen-Ion Concentration
Mass Spectrometry
Mutation
Prealbumin
Protein Binding
Protein Conformation
Thyroxine

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