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Article

Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation.

Journal of molecular biology - 15 Aug 2024

Leach Benjamin I, Ferguson James A, Morgan Gareth, Sun Xun, Kroon Gerard, Oyen David, Dyson H Jane, Wright Peter E

Abstract excerpt

The aggregation pathway of transthyretin (TTR) proceeds through rate-limiting dissociation of the tetramer (a dimer of dimers) and partial misfolding of the resulting monomer, which assembles into amyloid structures through a downhill polymerization mechanism. The structural features of the aggregation-prone monomeric intermediate are poorly understood. NMR relaxation dispersion offers a unique opportunity to...

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Identifiers

PMID: 38909653
DOI: 10.1016/j.jmb.2024.168673
PMCID: PMC11410348

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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