Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis.

doi:10.1016/j.bbr.2022.113891

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Article

Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis.

Behavioural brain research - 25 Jun 2022

Caruso Alessandra, Ricceri Laura, Caruso Angela, Nicoletti Ferdinando, Gaetano Alessandra, Scaccianoce Sergio

Abstract excerpt

Adolescence is a critical period for brain development. In most mammalian species, disturbances experienced during adolescence constitute a risk factor for several neuropsychiatric disorders. In this study, we compared the biochemical and behavioral profile induced by postweaning social isolation (PWSI) in inbred C57BL/6 N mice with that of BTBR mice, a rodent model of autism spectrum disorders. Male C57BL/6 N...

Topics

Animals
Autistic Disorder
Disease Models, Animal
Male
Mammals
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Phenotype
Receptors, Metabotropic Glutamate
Social Behavior
Social Isolation

Source

Open in PubMed

Identifiers

PMID: 35421428
DOI: 10.1016/j.bbr.2022.113891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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