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Article

The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2016

Roe Jae-Seok, Vakoc Christopher R

Abstract excerpt

Acute myeloid leukemia (AML) is often initiated by genetic alterations of machineries that regulate chromatin and transcription, thereby blocking cell differentiation. Such mechanisms may also render leukemia cells vulnerable to perturbations of transcriptional regulators, which includes small molecules targeting the coactivator protein BRD4. Numerous studies have validated BRD4 as a therapeutic target in diverse...

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Topics

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Share to Cell Cycle Proteins
Share to Chromatin
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Nuclear Proteins

Share to Transcription Factors

Share to Transcription, Genetic

Source

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Identifiers

PMID: 28174254
DOI: 10.1101/sqb.2016.81.031039
PMCID: PMC5550326

Genes

BRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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