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Article

BLM mutation is associated with increased tumor mutation burden and improved survival after immunotherapy across multiple cancers.

Cancer medicine - 1 Jan 2024

Shi Huiping, Gao Liang, Yin Hong, Jiang Min

Abstract excerpt

BACKGROUND: BLM encodes a RecQ DNA helicase that regulates genomic stability, and its mutations are associated with increased cancer susceptibility. Here, we show a multifaceted role of BLM mutations in tumorigenesis and immunotherapy. METHODS AND RESULTS: A total of 10,967 cancer samples from the cancer genome atlas database were analyzed, 1.6% of which harbored BLM somatic mutations. BLM mutation was found to...

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Identifiers

PMID: 38124443
DOI: 10.1002/cam4.6716
PMCID: PMC10807622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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