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Article

Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study.

Cardiovascular diabetology - 20 Dec 2023

Hu Jinbo, Zeng Qinglian, Chen Xiangjun, Luo Wenjin, Tang Ziwei, Mei Mei, Zhao Wenrui, Du Zhipeng, Liu Zhiping, Li Qifu, Cheng Qingfeng, Yang Shumin

Abstract excerpt

BACKGROUND AND AIMS: Primary aldosteronism (PA) is an adrenal disorder of autonomous aldosterone secretion which promotes arterial injury. We aimed to explore whether PA is causally associated with lower-extremity arterial disease (LEAD). METHODS: We included 39,713 patients with diabetes and 419,312 participants without diabetes from UK Biobank. We derived a polygenic risk score (PRS) for PA based on previous...

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Identifiers

PMID: 38124109
DOI: 10.1186/s12933-023-02086-x
PMCID: PMC10734059

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