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Article

Screening of the key single nucleotide polymorphisms in type 2 diabetes mellitus complicated with lower extremity arterial disease by machine learning.

Journal of hypertension - 1 Jan 2026

Li Xinyi, Yang Aige, Liu Xiao, Xu Shunjiang, Zhou Huimin

Abstract excerpt

OBJECTIVES: Diabetic lower extremity arterial disease (LEAD) is a manifestation of diabetic lower extremity vascular complications. This study aimed to screen the key single nucleotide polymorphism (SNP) gene signature in patients with type 2 diabetes mellitus (T2DM) and LEAD. METHODS: A total of 147 patients with T2DM complicated by LEAD and 144 patients with T2DM without LEAD were enrolled for transcriptome...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Polymorphism, Single Nucleotide
Machine Learning
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Lower Extremity

Aged

Peripheral Arterial Disease

Diabetic Angiopathies

Source

Identifiers

PMID: 41230927
DOI: 10.1097/HJH.0000000000004164

Genes

APOA1
APOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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