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Article

Primary Aldosteronism Influences Cardiac Structure, Function, and Disease Risk: Evidence From Mendelian Randomization Analysis.

Journal of clinical hypertension (Greenwich, Conn.) - 1 Nov 2024

Shen Rui, Pan Chengliang, Yu Jian, Dong Chen, Li Zhiyang, Zhang Jiangmei, Dong Qian, Yu Kunwu, Zeng Qiutang

Abstract excerpt

Although observational studies have linked primary aldosteronism (PA) with cardiovascular diseases (CVDs), the causality remains uncertain. In this study, we aimed to investigate whether PA is causally associated with CVD risk and cardiac magnetic resonance (CMR) parameters using the Mendelian randomization (MR) method. Independent and genome-wide significant single nucleotide polymorphisms for PA were extracted...

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Identifiers

PMID: 39373632
DOI: 10.1111/jch.14912
PMCID: PMC11555523

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