The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine.

doi:10.3390/ijms231810481

Article

The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine.

International journal of molecular sciences - 9 Sept 2022

Butnariu Lăcrămioara Ionela, Gorduza Eusebiu Vlad, Florea Laura, Țarcă Elena, Moisă Ștefana Maria, Tradafir Laura Mihaela, Cojocaru Elena, Luca Alina-Costina, Stătescu Laura, Bădescu Minerva Codruța

Abstract excerpt

Lower extremity artery disease (LEAD), caused by atherosclerotic obstruction of the arteries of the lower limb extremities, has exhibited an increase in mortality and morbidity worldwide. The phenotypic variability of LEAD is correlated with its complex, multifactorial etiology. In addition to traditional risk factors, it has been shown that the interaction between genetic factors (epistasis) or between genes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine.

Abstract excerpt

Topics

Related research