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Article

Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.

PLoS genetics - 1 Dec 2023

Fritsche Lars G, Nam Kisung, Du Jiacong, Kundu Ritoban, Salvatore Maxwell, Shi Xu, Lee Seunggeun, Burgess Stephen, Mukherjee Bhramar

Abstract excerpt

OBJECTIVE: To overcome the limitations associated with the collection and curation of COVID-19 outcome data in biobanks, this study proposes the use of polygenic risk scores (PRS) as reliable proxies of COVID-19 severity across three large biobanks: the Michigan Genomics Initiative (MGI), UK Biobank (UKB), and NIH All of Us. The goal is to identify associations between pre-existing conditions and COVID-19...

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PMID: 38113267
DOI: 10.1371/journal.pgen.1010907
PMCID: PMC10763941

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