Article
Case-control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing.
Epidemiology and infection - 26 Dec 2024
Nostaeva Arina, Shimansky Valentin, Apalko Svetlana, Kuznetsov Ivan, Sushentseva Natalya, Popov Oleg, Asinovskaya Anna, Mosenko Sergei, Karssen Lennart, Sarana Andrey, Aulchenko Yurii, Shcherbak Sergey
Abstract excerpt
The course of COVID-19 is highly variable, with genetics playing a significant role. Through large-scale genetic association studies, a link between single nucleotide polymorphisms and disease susceptibility and severity was established. However, individual single nucleotide polymorphisms identif...
Topics
- Humans
- COVID-19
- Male
- Female
- Russia
- Middle Aged
- Multifactorial Inheritance
- Case-Control Studies
- Polymorphism, Single Nucleotide
- Severity of Illness Index
- Genetic Predisposition to Disease
- Adult
- Genome-Wide Association Study