Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Case-control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing.

Epidemiology and infection - 26 Dec 2024

Nostaeva Arina, Shimansky Valentin, Apalko Svetlana, Kuznetsov Ivan, Sushentseva Natalya, Popov Oleg, Asinovskaya Anna, Mosenko Sergei, Karssen Lennart, Sarana Andrey, Aulchenko Yurii, Shcherbak Sergey

Abstract excerpt

The course of COVID-19 is highly variable, with genetics playing a significant role. Through large-scale genetic association studies, a link between single nucleotide polymorphisms and disease susceptibility and severity was established. However, individual single nucleotide polymorphisms identified thus far have shown modest effects, indicating a polygenic nature of this trait, and individually have limited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Russia

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 39721951
DOI: 10.1017/S0950268824001778
PMCID: PMC11748017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Case-control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing.PMID 39721951Read ↗

Analysis of associations between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencingSemantic proximity Read ↗

Genetic associations with severe COVID-19Semantic proximity Read ↗

Hypotheses and facts for genetic factors related to severe COVID-19Semantic proximity Read ↗

Assessing the potential of polygenic scores to strengthen medical risk prediction models of COVID-19.Semantic proximity Read ↗

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.Semantic proximity Read ↗

A comprehensive knowledgebase of known and predicted human genetic variants associated with COVID-19 susceptibility and severitySemantic proximity Read ↗

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severitySemantic proximity Read ↗

A Unique Patient Stratification Method Combined with a Machine Learning Approach Identifies Novel Genetic Susceptibility and Protective Factors for Severe COVID-19 in a Hungarian Population.Semantic proximity Read ↗

Multi-Layered Genomic and Clinical Analysis Identifies Novel Variants, Co-Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host-Pathogen Interaction in COVID-19 Severity.Semantic proximity Read ↗

Post-Mendelian Genetic Model in COVID-19Semantic proximity Read ↗

Worldwide distribution of genetic factors related to severity of COVID-19 infection.Semantic proximity Read ↗

Clinical Scenario Predicting the Genetic Susceptibility for Severity of COVID-19 Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.