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Article

TRIM28 congenital predisposition to Wilms' tumor: novel mutations and presentation in a sibling pair.

Cold Spring Harbor molecular case studies - 1 Aug 2020

Moore Colin, Monforte Hector, Teer Jamie K, Zhang Yonghong, Yoder Sean, Brohl Andrew S, Reed Damon R

Abstract excerpt

Wilms' tumor is the most common renal malignancy in children. In addition to staging, molecular risk stratification, such as loss of heterozygosity (LOH) in Chromosomes 1 and 16, is being increasingly used. Although genetic predisposition syndromes have been well-characterized in some Wilms' tumors, recent sequencing and biology efforts are expanding the classification of this malignancy. Here we present a case...

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Identifiers

PMID: 32699065
DOI: 10.1101/mcs.a004796
PMCID: PMC7476416

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