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Article

Genotyping of cerebrospinal fluid in lung cancer patients with leptomeningeal metastasis.

Thoracic cancer - 1 Sept 2022

Nie Naifu, Zhou Haodong, Zhang Kejun, Liu Lan, Luo Nuo, Wang Renyuan, Li Xin, Zhu Mengxiao, Hu Chen, Wang Yubo, Liu Zhulin, Li Li, He Yong

Abstract excerpt

BACKGROUND: The prognosis of non-small-cell lung cancer (NSCLC) with leptomeningeal metastasis (LM) is poor. Detection of cell-free DNA (cfDNA) by next generation sequencing (NGS) in cerebrospinal fluid (CSF) may facilitate diagnosis of LM and identification of drug resistance mechanisms, yet its clinical use needs to be further verified. METHODS: We performed a retrospective cohort study to assess the genetic...

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Identifiers

PMID: 35896160
DOI: 10.1111/1759-7714.14592
PMCID: PMC9475227

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