Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma.

doi:10.1158/1078-0432.CCR-14-0519

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Article

Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2015

Choi Seongmin, Kim Hyeong Ryul, Sung Chang Ohk, Kim Jongkyu, Kim Sukjun, Ahn Sung-Min, Choi Chang-min, Chun Sung-Min, Choi Eun Kyung, Kim Sang-We, Kim Yong-Hee, Lee Ji-Young, Song Joon Seon, Kim Deokhoon, Haq Farhan, Lee Sun Young, Lee Jong-eun, Jung Wang-rim, Jang Hye Yoon, Yang Eunho, Lee Charles, Yu Eunsil, Kong Gu, Baek Daehyun, Jang Se Jin

Abstract excerpt

PURPOSE: To better understand the complete genomic architecture of lung adenocarcinoma. EXPERIMENTAL DESIGN: We used array experiments to determine copy number variations and sequenced the complete exomes of the 247 lung adenocarcinoma tumor samples along with matched normal cells obtained from the same patients. Fully annotated clinical data were also available, providing an unprecedented opportunity to assess...

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PMID: 25294902
DOI: 10.1158/1078-0432.CCR-14-0519

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