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Pan-Cancer Somatic Pharmacogenomic Variant Landscape: Cross-Referencing TCGA Somatic Mutations with PharmVar/CPIC Star-Allele Definitions Across CYP2D6, CYP2C19, DPYD, and TPMT

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Background Pharmacogenomics classically characterises drug metabolism phenotypes from germline polymorphisms. However, somatic mutations acquired during oncogenesis can disrupt pharmacogene function, potentially overriding or compounding a patient's inherited metaboliser phenotype. The clinical consequences of tumour-acquired pharmacogene loss-of-function remain poorly characterised at...

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Literature Corpus work: b8c5a7c9-4090-5c99-8f18-08c3d7906e74
DOI: 10.21203/rs.3.rs-9414766/v1

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Pan-Cancer Somatic Pharmacogenomic Variant Landscape: Cross-Referencing TCGA Somatic Mutations with PharmVar/CPIC Star-Allele Definitions Across CYP2D6, CYP2C19, DPYD, and TPMTDOI 10.21203/rs.3.rs-9414766/v1Read

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