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Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions

14 Dec 2023

Abstract excerpt

The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility, facilitates its immune escape, impairs vaccine efficacy, and currently causes repeated infections in human, which is mainly determined by the accumulated mutations in spike (S). 1 Transmembrane S is a heavily glycosylated protein on the surface of the virion as homotrimer, responsible for binding to human...

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PMID: 38097565
DOI: 10.1038/s41392-023-01719-7

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