Article
Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement.
Breast (Edinburgh, Scotland) - 1 Feb 2024
Schwartz Mathias, Ibadioune Sabrina, Vacher Sophie, Villy Marie-Charlotte, Trabelsi-Grati Olfa, Le Gall Jessica, Caputo Sandrine M, Delhomelle Hélène, Warcoin Mathilde, Moncoutier Virginie, Bourneix Christine, Boutry-Kryza Nadia, De Pauw Antoine, Stern Marc-Henri, Buecher Bruno, Mouret-Fourme Emmanuelle, Colas Chrystelle, Stoppa-Lyonnet Dominique, Masliah-Planchon Julien, Golmard Lisa, Bieche Ivan
Abstract excerpt
Breast cancers (BC) are rare in men and are often caused by constitutional predisposing factors. In women, mosaic BRCA1 promoter methylations (MBPM) are frequent events, detected in 4-8% of healthy subjects. This constitutional epimutation increases risk of early-onset and triple-negative BC. However, the role of MBPM in male BC predisposition has never been assessed. We screened 40 blood samples from men...
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