A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy.

doi:10.1016/j.breast.2017.12.013

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Article

A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy.

Breast (Edinburgh, Scotland) - 1 Apr 2018

Silvestri Valentina, Rizzolo Piera, Zelli Veronica, Valentini Virginia, Zanna Ines, Bianchi Simonetta, Tibiletti Maria Grazia, Varesco Liliana, Russo Antonio, Tommasi Stefania, Coppa Anna, Capalbo Carlo, Calistri Daniele, Viel Alessandra, Cortesi Laura, Manoukian Siranoush, Bonanni Bernardo, Montagna Marco, Palli Domenico, Radice Paolo, Peterlongo Paolo, Ottini Laura

Abstract excerpt

INTRODUCTION: Breast cancer (BC) in men is a rare disease, whose etiology appears to be associated with genetic factors. Inherited mutations in BRCA1/2 genes account for about 10-15% of all cases. FANCM, functionally linked to BRCA1/2, has been suggested as a novel BC susceptibility gene. Our aim was to test if FANCM germline mutations could further explain male BC (MBC) susceptibility. METHODS: We screened the...

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Identifiers

PMID: 29287190
DOI: 10.1016/j.breast.2017.12.013

Genes

FANCM
BRCA1

Variants

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